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Basic information on S.suis

  1. one of the most prevalent pathogens in swine causing a range of disease syndromes including arthritis (关节炎), meningitis (脑膜炎), pneumonia (肺炎), septicemia (败血症) and endocarditis (心内膜炎), etc. [1]
  2. an zoonotic agent able to induce meningitis, endocarditis, and streptococcal toxic shock-like syndrome in humans. [1]
  3. Thirty three S. Suis serotypes identified on the basis of antigenic differences in their CPS (Capsule Polysacharides). [1]
  4. S. suis 2 mainly infects people who have direct contact with carrier pigs, sick pigs, or raw pork via wounds on the skin, or the mucosa of the mouth, or nasal cavity. [1]
  5. 1642 cases of S. suis human infection had been reported worldwide until Dec. 31, 2013. [1]

[1]. Zhang, Y., Ding, D., Liu, M., Yang, X., Zong, B., Wang, X., Chen, H., Bei, W., and Tan, C. (2016). Effect of the glycosyltransferases on the capsular polysaccharide synthesis of Streptococcus suis serotype 2. Microbiological research.

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Effect of the glycosyltransferases [糖基转移酶] on the CPS [荚膜多糖] synthesis of S.suis 2

  1. The incomplete CPS resulting from deletion of the cps genes in S.suis 2 SC19;
  2. Interplay between S.suis 2 SC19 and different cell lines in vitro changed by these
    genes deletion
    cps2E, cps2G, cps2J and cps2L
  3. More deposition on the mutant strains of complement C3 in porcine serum
    than on WT
  4. Essential role of the cps genes in viability of SC19 in a murine model

Zhang, Y., Ding, D., Liu, M., Yang, X., Zong, B., Wang, X., Chen, H., Bei, W., and Tan, C. (2016). Effect of the glycosyltransferases on the capsular polysaccharide synthesis of Streptococcus suis serotype 2. Microbiological research.