Division of Medical Sciences at Harvard Medical School (DMS)

Bioinformatics and Integrative Genomics (BIG)

The Bioin­for­mat­ics and Inte­gra­tive Genomics (BIG) Pro­gram enrolls PhD stu­dents with excep­tion­al train­ing in quan­ti­ta­tive sci­ences and strong inter­est in bio­med­ical appli­ca­tions. Research areas encom­pass com­pu­ta­tion­al analy­sis and math­e­mat­i­cal mod­el­ing of data gen­er­at­ed by DNA sequence, gene expres­sion, struc­tural, pro­teomics, and metabo­lite-assay­ing tech­nolo­gies. In applied projects, they may also include inte­gra­tion of clin­i­cal and pop­u­la­tion data from elec­tron­ic health records. Both bioin­for­mat­ics and genomics are tight­ly linked to the math­e­mat­i­cal and bio­phys­i­cal mod­el­ing of com­plex bio­log­i­cal sys­tems and exper­i­men­tal val­i­da­tion of com­pu­ta­tion­al pre­dic­tions. Grad­u­ate stu­dents will con­duct orig­i­nal research in the devel­op­ment of nov­el approach­es and new tech­nolo­gies to address fun­da­men­tal bio­log­i­cal ques­tions, and they will acquire the skills to be lead­ers in the field of bioin­for­mat­ics and genomics. Stu­dents will be joint mem­bers of BIG and a “home pro­gram” cho­sen from one of the four DMS pro­grams (BBS, Immunol­o­gy, Neu­ro­science, Virol­o­gy). BIG stu­dents will fol­low the cur­ricu­lum and par­tic­i­pate in activ­i­ties of the home pro­gram, which will be sup­ple­ment­ed with BIG pro­gram­mat­ic and cur­ric­u­lar offer­ings.

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